The "silent mutations" are not harmless.

The reason why some mutations are silent is simple. Cells read the DNA sequence, where the silent mutation locates seldom.

And those DNA sequences control the development of neurons and the nervous system. There is no junk DNA in human genomes. So every genetic abnormal is dangerous.

When people are talking about things like "silent mutations" they should understand that the thing that makes mutation silent is that its location is in the DNA sequences that are not read very often. If the cells don't read the DNA sequences very often that means they don't need that data very often. So what that kind of data is? Those DNA sequences that are read seldom involve information that is needed for cells that are splitting very seldom.

So those "silent mutations" are in the areas where is information. That controls the development of the nervous system. And that kind of mutation involves the greatest risks. The error in the genetic code that controls the development of the neurons is always causing a big risk. Things like retroviruses can cause errors in genetic material. And there is the possibility that also descendants of the infected person will get those damaged genomes.

The problem is that if the virus writes its genomes to DNA sequences that are controlling the neurons the neurons don't need those DNA sequences anymore. Or the damage in genetic code is in genital cells. So the DNA of the neurons is not damaged. But genital cells can transfer that genetic damage to descendants.

That means the genetic damages can be invisible. If cells are already ready those DNA sequences might not read. That means that if the damaged sequence is transmitted to the next generation the descendants can get visible genetic disorders even if their parents are wealthy.

https://scitechdaily.com/disproving-a-60-year-old-hypothesis-most-silent-mutations-are-actually-harmful/

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